Many people have a fear and hatred of reptiles, and this often includes lizards. However, for the most part lizards are completely harmless to people. In North America, there are only two species of venomous lizard. These are the Gila Monster (Heloderma suspectum) and the Mexican Beaded Lizard (Heloderma horridum). In the case of the Gila Monster, the bite is considered non-threatening to healthy adults. Due to current medical treatments, fatalities of any kind are almost unheard of. No fatal bites have been recorded since 1939. Almost all bites occur due to someone harassing the lizards, or accidentally stepping on one. Gila Monsters do not look for people to bite, nor do they go out of their way to attack.
The same is true for the Mexican Beaded Lizard (Heloderma horridum). In the last century, only eight bites have been recorded. Almost all of these were captive lizards biting keepers who prodded them with bare hands or feet.
There is some disagreement among the scientific community on whether or not the monitor lizards (Varanidae) and Agamids (Agamidae) are somewhat venomous. The only other species of lizard though that can generally be of any threat to humans is the Komodo Dragon (Varanus komodoensis). However, attacks on humans are rare.
Generally, lizards are harmless to humans and actually provide many benefits to people. Find out more about this here.